Results of renal transplantation in patients with past history of hepatitis C in Guilan province

موضوع: 2005/13

نویسندگان:

استاد راهنما:

خلاصه:

Khosravi M. Journal of Guilan University of Medical Sciences. 2005 Jan 15; 13(52):65-70.

شماره: 1

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Journal of Guilan University of Medical Sciences. 2005 Jan 15; 13(52):65-70.
Results of renal transplantation in patients with past history of hepatitis C in Guilan province.
Masoud Khosravi
ABSTRACT                                                         Full-Text PDF
Introduction: Patients with hepatitis C infection who are candidates for renal transplantation, can undergo renal transplantation if hepatitis C is inactive and without any liver cirrhosis. After renal transplantation due to induced immunosupression, hepatitis C virus can be reactivated and cause progression of liver disease as well as kidney transplant involvement (glomerulonephritis, rejection).
Objective: The purpose of this study was to evaluate the results of renal transplantations in patients with a past history of hepatitis C involvement.
Materials and Methods: This research is a cross-sectional study on 14 patients with a past history of hepatitis C from a total of 60 patients who had passed one year after kidney transplantation, and between 1998- 2001, of 14 patients, 10 people had liver biopsy before transplantation.HCV-RNA was negative in the patients at the time of transplantation and after that, immunosuppressive drugs used were prednisolone, ciclospori, azathioprine, and mycophenolatemophetile. Then, data were analyzed by SPSS.10
Results: One year after transplantation, no detrimental effects were seen in those patients with a past history of hepatitis C on liver and transplanted kidney, life time of patient and graft survival. HCV-RNA was negative. Rejection cases were seen.in 4 casesout of 14 patients with hepatitis C, that was not due to hepatitis C. No glomerulonephritis cases were seen posttransplantation. The mean plasma Creatinine was 1.18 mg/dl. No side effects of immunosupressive drugs were seen on liver of these 14 patients. Only two persons among 14 patients died because of cardiovascular problems and cytomegalovirus infection.
Conclusion: This study showed that short- term consequences in our patients with a past history of hepatitis C infection in comparison with those who were not infected with hepatitis C one year post-transplantation, were generally good.

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Cytomegalovirus disease with atypical presentation in a renal transplant patient: case report

موضوع: 2006/4

نویسندگان:

استاد راهنما:

خلاصه:

Khosravi M, Nobakht A, Nikokar AR. Exp Clin Transplant. 2006 Jun; 4(1):458-61.

شماره: 2

واحد صادرکننده:

جزئیات

Experimental and Clinical Transplantation, 2006 Jun; 4(1):458-61.

Cytomegalovirus Disease with Atypical Presentation in a Renal Transplant Patient: Case Report

Masoud Khosravi,1 Ali Nobakht,2 Abdolah R Nikokar3

1Division of Nephrology, Gilan University of Medical Sciences, Gilan, Iran

2Division of Nephrology, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3Division of Pathology, Gilan University of Medical Sciences, Gilan, Iran


Address reprint requests to:

Masoud Khosravi, Golsar, Street 142, No: 25, Postal Code: 4165763355, Rasht, Iran
Phone: 00 989 11 131 5796
Fax: 00 981 31 772 1728
E-mail: drmasoudkhosravi@yahoo.com

ABSTRACT                                                         Full-Text PDF

Infection is a major problem after kidney transplantation. Cytomegalovirus (CMV) is the most common viral infection affecting transplant patients. This report presents a rare clinical manifestation of CMV in the form of a hemorrhoid in a 58-year-old woman. One week after undergoing an external hemorrhoidectomy, the patient presented with fever, leukopenia, and thrombocytopenia. Pathological analysis showed CMV in the hemorrhoidal tissue, which was confirmed via a positive PP65 antigenemia assay. Therapy with ganciclovir (250 mg IV b.i.d. for 2 weeks) was started. The patient’s response to treatment was good, and she has been doing well since that time. Her plasma creatinine level 2 years later was 79.2 µmol/L (normal range, 53-106 µmol/L). Physicians must always be aware of the hatahomads of CMV in immunocompromised patients with typical, and even with atypical, presentations. Taking into consideration the statement, “prophylaxis precedes treatment,” nephrologists must try to detect CMV in their patients (especially during the first 6 months after transplantation) prior to the appearance of any clinical manifestations. If CMV is detected, pre-emptive therapy with ganciclovir should be started.

Key words: Cytomegalovirus infection, Kidney transplantation, Immunosuppression, Endothelial cells

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Acute renal failure due to leptospirosis in a renal transplant recipient: a brief review of the literature

موضوع: 2007/39

نویسندگان:

استاد راهنما:

خلاصه:

Khosravi M, Bastani B. Transplant Proc. 2007 May; 39(4):1263-6. doi:10.1016/j.transproceed.2007.03.036

شماره: 3

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Transplantation Proceedings, 2007 May; 39(4):1263-6. doi: 10.1016/j.transproceed.2007.03.036

Acute renal failure due to leptospirosis in a renal transplant recipient: a brief review of the literature.

M. Khosravi and B. Bastani

ABSTRACT                                                         Full-Text PDF

We present the case of a 43-year-old renal transplant patient who presented with fever, malaise, pruritus, headache, and severe jaundice of 3-week duration following work in a rice field. He was found to have acute renal failure and severe hyperbilirubinemia with a positive serum leptospira antibody titer, making the diagnosis of Weil’s disease. The patient responded to reduction in immunosuppressive medications and intravenous penicillin therapy with no need for dialysis. This is the second case of leptospirosis in a kidney transplant patient reported in the English literature.

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Improvement of maximum corrected QT and corrected QT dispersion in electrocardiography after kidney transplantation

موضوع: 2008/2

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Ghods AJ. Iran J Kidney Dis. 2008 Apr; 2(2):95-8.

شماره: 4

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Iran J Kidney Dis. 2008 Apr; 2(2):95-8.
Improvement of maximum corrected QT and corrected QT dispersion in electrocardiography after kidney transplantation.
Ali Monfared,1 Ahad Jafari Ghods2
1Department of Internal Medicine and Urology Research Center, Guilan University of Medical Sciences, Rasht, Iran
2Department of Nephrology and Transplantation, Hasheminejad Hospital, Iran University of Medical Science, Tehran, Iran
ABSTRACT                                                         Full-Text PDF
Introduction: The electrocardiography (ECG) markers of corrected QT interval (QTc) and QTc dispersion are prolonged in patients on hemodialysis. This study was carried out to investigate if changes in these markers will reverse by successful kidney transplantation.
Materials and Methods: Twenty-six kidney allograft recipients with functioning grafts, 26 patients on maintenance hemodialysis, and 22 healthy individuals were underwent a 12-lead ECG and laboratory studies for electrolytes and arterial blood gas. In the patients on dialysis, ECG and laboratory studies were performed prior to the start of a hemodialysis session. Both QT dispersion and maximum QT were corrected for heart rate (QTc dispersion and maximum QTc). The results were compared between the three groups.
Results: The mean QTc dispersion was 30.3±15.2 ms, 27.6±8.3 ms, and 24.5±9.0 ms, and the mean maximum QTc was 464.7±23.0 ms, 436.3±19.0 ms, and 415.0±85.0 ms in the patients on dialysis, transplant recipients, and controls, respectively. The QTc dispersion value was lower in the transplant group than in the hemodialysis group, but the differences were not statistically significant. Whereas, the maximum QTc was significantly shorter in the transplant recipients as compared with the patients on hemodialysis (P<0.02). There was a significant correlation between the maximum QTc and serum calcium level (P<0.001), serum magnesium level (P<0.001), and pH (P<0.001).
Conclusions: Prolonged maximum QTc decreases towards normal by successful kidney transplantation. These corrections are most likely due to normalization of electrolytes and the acid-base status from a uremic state to the normal kidney function.

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Gastrointestinal and liver malignancies after renal transplantation: a multicenter study

موضوع: 2009/1

نویسندگان:

استاد راهنما:

خلاصه:

Nafar M, Lessan-Pezeshki M, Shahbazian H, Pour-Reza-Gholi F, Firouzan A, Ahmadpour P, Makhdomi K, Ghafari A, Ardalan MR, Roozbeh J, Jalalzadeh M, Ghadiani MH, Khosravi M, Razeghi E. Int J Nephrol Urol. (Nephro-Urology Monthly) 2009 June; 1(1, Summer):33-38.

شماره: 5

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International Journal of Nephrology & Urology, 2009; 1(1): 33 – 38
Gastrointestinal and Liver Malignancies after Renal Transplantation: A Multicenter Study
Mohsen Nafar1*, Mahboob Lessan-Pezeshki2, Heshmatollah Shahbazian3, Fatemeh Pour-Reza Gholi1, Ahmad Firouzan1, Pedram Ahmadpour1, Khadidheh Makhdomi4, Ali Ghafari4, Mo­hammad Reza Ardalan5, Jamshid Roozbeh6, Mojgan Jalalzadeh7, Mohmmad Hassan Ghad­iani8, Masoud Khosravi9, Efat Razeghi2
1Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Nephrology, Tehran University of Medical Sciences, Tehran, Iran
3Department of Nephrology, Ahvaz University of Medical Sciences, Ahvaz, Iran
4Department of Nephrology, Urmia University of Medical Sciences, Urmia, Iran
5Department of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran
6Department of Nephrology, Shiraz University of Medical Sciences, Shiraz, Iran
7Department of Nephrology, Zanjan University of Medical Sciences, Zanjan, Iran
8Legal Medicine Organization of I.R. I, Tehran, Iran
9Department of Nephrology, Rasht University of Medical Sciences, Rasht, Iran
*Correspondence: Mohsen Nafar, MD
Department of Nephrology, Labbafi-Nejad Hospital, 9th Boostan St. Pasdaran St. Tehran-Iran
E-Mail: nafar@sbmu.ac.ir
Received: 12 Mar 2009; Revised: 8 Apr 2009; Accepted: 16 Apr 2009
ABSTRACT                                                         Full-Text PDF
Background: Immunosuppression increases the incidence of cancer and promotes the growth of neoplasm in kidney transplant recipients. There have been few reports on the incidence of gastrointestinal (GI) and liver cancers from transplant registries.
Methods: In the current study, we collected data from 8 kidney transplant centers in Iran between 1984 and 2008, to detect the incidence, type, and outcome of GI and liver cancers after kidney transplantation. Only histologically confirmed tumors that occurred after renal transplantation were included in the analysis. We also compared their data with 3028 kidney recipients of two transplant centers.
Results: Of the 9355 patients who underwent kidney transplantation, GI tumors were detected in 14 (0.15%), 12 males and 2 females. Male gender was predominant between patients with GI and liver tumors (P=0.02). Colorectal carcinoma (CRC) was the most common GI cancer (n=7) followed by gastric adenocarcinoma (n=3) and hepatocellular carcinoma (n=3). Mean age of patients was 48.0±10.6 (27–61) years and mean time of diagnosis since transplantation was 72 (5-284) months. Significant risk factors for the development of a de novo malignancy were male gender, older age (>50 years of age) and the total time on immunosuppression. Patient and graft survival rates from the time of GI and liver cancers onset were poor.
Conclusions: CRC was the most common GI tumor following kidney transplantation and was predominant in male. GI and liver malignancies have poor prognosis and early diagnosis and prompt treatment of the post-transplant malignancies is essential.
Keywords: Kidney Transplantation, Gastrointestinal Neoplasm, Liver, Colorectal Carcinoma

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Pulmonary hydatid cyst and successful renal transplantation

موضوع: 2009/23

نویسندگان:

استاد راهنما:

خلاصه:

Aghajanzadeh M, Monfared A, Mokhtari GR, K Lebady M, Poorreza F, Orangpour R. Medical Journal of the Islamic Republic of Iran (MJIRI). 2009 May 15; 23(1):48-52.

شماره: 6

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Medical Journal of the Islamic Republic of Iran (MJIRI). 2009 May 15; 23(1):48-52.
Case Report
Pulmonary hydatid cyst and successful renal transplantation.
Manoucher Aghajanzadeh1, MD; Ali Monfared2, MD; Gholam-Reza Mokhtari3, MD; Masood khosravi4, MD; Mohamad K Lebady5, MD; Farshid Poorreza6, MD; Reza Orangpour7, MD.
1Corresponding author, Assistant Professor of Thoracic Surgery, Guilan University of Medical Sciences. No. 37, 100th Ave. Golsar Rasht, Iran. Tel: +98131 7722389, email: Maghajanzadeh2003@yahoo.com.
2&4&5Department of Nephrology, Guilan University of Medical Sciences Rasht, Iran.
3&6Transplantation and Urology, Guilan University of Medical Sciences Rasht, Iran.
7General Practitioner.
ABSTRACT                                                         Full-Text PDF
Hydatid cysts are endemic hooknoses in Iran. It may involve various organs of body. Liver is involved in 80% and lung in 10- 15%of cases. 25% of pulmonary hydatid cyst is bilateral. Before any transplantations eradication of infection is necessary. In a 26-year old man with renal failure referred for kidney transplantation. On initial preoperative evaluation of this patient hydatid cyst lesion was found in two lungs, left side operated, and right side left in place. Under treatment with albendazole kidney transplantation was performed. After two-year of follow-up, patient was in good condition and the size of right cyst did not increased.
Keywords: pulmonary hydatid cyst, kidney transplantation, immunosuprresion, albendasol.

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En bloc bilateral kidney, aorta, and vena cava transplantation from a deceased pediatric donor to an adult recipient: a case report

موضوع: 2010/3

نویسندگان:

استاد راهنما:

خلاصه:

Mokhtari G, Pourreza F, Asgari SA, Hemmati H, Enshaei A, Emadi SA, Afsharimoghaddam A. UroToday International Journal. 2010 Oct 1; 3(5). doi:10.3834/uij.1944-5784.2010.10.04

شماره: 7

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UroToday International Journal. 2010 Oct 1; 3(5). doi:10.3834/uij.1944-5784.2010.10.04
En bloc bilateral kidney, aorta, and vena cava transplantation from a deceased pediatric donor to an adult recipient: a case report.
Gholamreza Mokhtari, Farshid Pourreza, Seyed Alaeddin Asgari, Hossein Hemmati, Ahmad Enshaei, Seyedeh Atefeh Emadi, Amin Afsharimoghaddam
Urology Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Submitted July 6, 2010 - Accepted for Publication August 23, 2010
Correspondence: Ahmad Enshaei, MD, Urology Research Center, Guilan University of Medical Sciences, Razi Hospital, Sardar Jangal Street, Rasht, Guilan, Iran (ahmad115@yahoo.com).
ABSTRACT                                                         Full-Text PDF
Kidney transplantation is the treatment of choice for end-stage renal disease. There has been reluctance to transplant small pediatric deceased donor kidneys into adults because of possible vascular and urinary complications and insufficient nephron mass. The present case is a successful renal transplantation from a pediatric cadaver donor to an adult recipient. Both kidneys and a segment of inferior vena cava (IVC) and aorta were resected en bloc. One end of both the aorta and IVC was completely closed; the other ends were anastomosed to the internal iliac artery and the external iliac vein of the recipient, respectively. Renal DTPA scan of the transplanted kidney showed good perfusion and function. Recipient BUN, creatinine, urinary output, and blood pressure were acceptable. There have been no complications or signs of rejection 20 months later. The use of the en bloc technique may obviate the otherwise adverse effect of very small donor size on transplantation outcome.
Key words: En bloc; Kidney transplant; End-stage renal disease

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Old male living renal transplant recipients more likely to be at risk for colorectal cancer

موضوع: 2011/43

نویسندگان:

استاد راهنما:

خلاصه:

Rostami Z, Einollahi B, Lessan-Pezeshki M, Nourbala MH, Nemati E, Pourfarziani V, Shahbazian H, Khosravi M, Jalalzadeh M. Transplant Proc. 2011 Mar; 43(2):588-9. doi:10.1016/j.transproceed.2011.01.073.

شماره: 8

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Transplantation Proceedings, 2011 Mar; 43(2):588-9. doi:10.1016/j.transproceed.2011.01.073.

Old male living renal transplant recipients more likely to be at risk for colorectal cancer.

Z. Rostami, B. Einollahi, M. Lessan-Pezeshki, M.H. Nourbala, E. Nemati, V. Pourfarziani, H. Shahbazian, M. Khosravi, and M. Jalalzadeh

ABSTRACT                                                         Full-Text PDF

Background: The development of posttransplant malignancy is a well-recognized complication of kidney transplantation due to immunosuppressive therapy. The literature on colorectal malignancy in living renal transplant recipients are limited; most of the data have been collected from deceased donor cases. As living kidney donation is now growing, we sought to define the characteristics and pattern of gastrointestinal malignancy among this group.

Methods: This cross-sectional, multicenter study analyzed the incidence and characteristics of colorectal malignancy among 17 patients with gastrointestinal malignancy after living donor renal transplantation between 1985 and 2009 in Iran. We observed a new-onset, biopsy-proven colorectal malignancy in eight patients of mean age 49.6±10.3 years (range=27–60) at transplantation time and a mean age of 61.1±8.6 years (range=53.4 –78.6) at cancer diagnosis.

Results: The cumulative incidence rate of colorectal malignancy of 0.03% was restricted to the male gender (100%), all of whom had functioning grafts. The mean period from transplantation to diagnosis was 99.7±10.4 months (range=5–284). The majority of the recipients were aged more than 50 years (n=5) and the most frequent immunosuppressive drug was azathioprine (n=5); none had received antithymocyte globulin/antilymphocyte globulin. It was mostly a late-onset malignancy with 50% of recipients presenting beyond 5 years from transplantation. They were followed for a mean of 9.2±2.4 (range=6–12) months after cancer diagnosis with three patients having succumbed within 9 months.

Conclusion: Due to the long latency after transplantation and the poor outcomes of colorectal malignancy these patients require long-term screening tests for early detection and due to their poor outcomes a new therapeutic approach.

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Muco-cutaneous manifestations in 178 renal transplant recipients

موضوع: 2011/25

نویسندگان:

استاد راهنما:

خلاصه:

Khosravi M, Golchai J, Mokhtari G. Clin Transplant. 2011 May-Jun; 25(3):395-400. doi:10.1111/j.1399-0012.2010.01284.x.

شماره: 9

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جزئیات

Clin Transplant. 2011 May-Jun; 25(3):395-400. doi:10.1111/j.1399-0012.2010.01284.x.

Muco-cutaneous manifestations in 178 renal transplant recipients.

Masoud Khosravi, Javad Golchai and Gholamreza Mokhtari

Department of Renal Transplantation and Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran

Corresponding author: Dr. Masoud Khosravi, Assistant Professor, Nephrologist, Nephrology Department, Guilan University of Medical Sciences, Renal Transplantation Ward, Razi Hospital, Sardar Gangal Street, 414489565 Rasht, Iran.

Tel.: 00981315537500; fax: 00981315530169; e-mail: masoud@gums.ac.ir

ABSTRACT                                                         Full-Text PDF

Introduction: Mucosal membrane and skin can be affected by immunosuppressive drug(s) and immunosuppression itself. The spectrum of muco-cutaneous lesions can range from malignancy at one end to infection, iatrogenic lesions, and esthetic effects on the other end.

Method: In Razi Hospital of Guilan University of Medical Sciences, a cross-sectional study for the detection of muco-cutaneous lesions in 178 renal transplant recipients (RTRs) was conducted from the years 2001 to 2006. Biopsy and skin scraping according to the type of skin lesions were performed.

Results: A total of 31 RTRs (25%) had normal skin. Iatrogenic lesions were the most common (70%) followed by infectious lesions (57%), and miscellaneous skin lesions were exhibited by 26% of the patients. Among the iatrogenic skin lesions, gingival hyperplasia was the most common lesion (48%), followed by hypertrichosis and acne. Malignant lesions (biopsy proven) were recorded in seven patients (5%). Four patients were found to have Kaposi_s sarcoma, and three patients were identified with basal cell carcinoma.

Conclusion: Our results showed that muco-cutaneous lesions are crucial problems with RTRs. Attending physicians must pay close attention to skin care regularly and consider reduction of immunosuppression to a safe level, and patient must have self-checkups.

Key words: immunosuppression – mucocutaneous lesions – renal transplantation

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Evaluation of graft survival renal transplant ward of Razi hospital, Rasht, north of Iran, from 1999 to 2010

موضوع: 2011/5

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Kohani M, Kazemnejad E, Khosravi M. Iran J Kidney Dis. 2011 November (Abstract Book of the 13th Congress of Nephrology, Dialysis, and Transplantation; YAZD 2011); 5(Supplement 2):25-25.

شماره: 10

واحد صادرکننده:

جزئیات

Iranian Journal of Kidney Diseases | Volume 5 | Supplement 2 | November 2011

13th International Congress of Nephrology, Dialysis and Transplantation—Poster Presentations

P204

Evaluation of Graft Survival Renal Transplant Ward of Razi Hospital, Rasht, North of Iran, From 1999 to 2010

Monfared A, Kohani M, Kazemnejad E, Khosravi M

Urology Research Center, Guilan University of Medical Sciences, Iran

ABSTRACT PDF

Introduction: Renal transplantation is the modality of choice for renal replacement therapy in the majority of ESRD patients. The survival of transplant kidney was improved significantly with introduce of new immunosuppressive regimens. In this study, we evaluated the renal transplant recipients’ graft survival in Razi hospital of Rasht in North of Iran, from 1999 to 2010.

Methods: All kidney transplant recipients in our center (n = 273) were studied. The demographic data were collected. Then 1-, 5-, and 10-year survival analyzed with analysis survival data and Kaplan-Meier curve. Chi-square test, Independent t test, and Mann-Whitney test were used for analysis of variants.

Results: In the study, 1-, 5-, and 10-year survival was 92.6%, 88%, and 77.5%, resectively. All grafts donated from living donors except 1 case. Delayed graft function significantly correlate with graft survival (P < .001).

Conclusions: In this study, 1-year survival was 92% and compared with multicenter study in USA (93.9%) showed good situation in this center. In addition, results of this study about effect of delayed graft function on graft survival are same to a study in Labafinejad hospital from 1985 to 2005.

Citation: Monfared A, Kohani M, Kazemnejad E, Khosravi M. Evaluation of graft survival renal transplant ward of Razi hospital, Rasht, north of Iran, from 1999 to 2010. Iran J Kidney Dis. 2011 November (Abstract Book of the 13th Congress of Nephrology, Dialysis, and Transplantation; YAZD 2011); 5(Supplement 2):25-25.

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QT intervals in patients receiving a renal transplant

موضوع: 2012/10

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Atrkar Roshan Z, Salari A, Asadi F, Lebadi M, Khosravi M, Besharati S. Exp Clin Transplant. 2012 Apr; 10(2):105-9. doi:10.6002/ect.2011.0117

شماره: 11

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جزئیات

Experimental and Clinical Transplantation, 2012 Apr; 10(2):105-9. doi: 10.6002/ect.2011.0117

QT intervals in patients receiving a renal transplant.

Ali Monfared,1 Zahra Atrkar Roshan,1 Arsalan Salari,2 Farshad Asadi,1Mohammadkazem Lebadi,1 Masoud Khosravi,1 Sepiedeh Besharati2

From the 1Urology Research Center, and the 2Cardiology Research Center, Guilan University of Medical Sciences, Urology Research Center, Razi Hospital, Rasht, Iran

Address reprint requests to: Ali Monfared, Urology Research Center, Guilan University of Medical Sciences, Urology Research Center, Razi Hospital, Sardar Jangal Street, Rasht, Iran
Phone: +98 911 3362634
Fax: +98 131 5525259
E-mail: drmonfared2009@gmail.com

ABSTRACT                                                        Full-Text PDF

Objectives: Cardiovascular disease is the most-common cause of mortality in patients with end-stage renal disease and renal transplant. Prolongation of QTcmax and QTc dispersion are risk factors of cardiac arrhythmias and mortality. This study compares the changes of QT parameters before hemodialysis, after hemodialysis, and after renal transplant.

Materials and Methods: Patient candidates for renal transplant were selected. Mean serum electrolyte and 12-lead electrocardiogram were recorded (1) immediately, (2) before and, (3) after the last dialysis session before renal transplant, (4) and 2 weeks after a kidney transplant in 34 patients with normal graft function (plasma Cr ≤ 176.8 µmol/L). Each QT interval was corrected for the patient’s heart rate using Bazett’s formula. The QT parameters (QTd, QTcd, QTcmax) were compared between prehemodialysis, post­hemodialysis, and 2 weeks after renal transplant using a paired t test and a general liner model repeated measure. The correlation between QT parameter changes and serum electrolyte and acid-base alternation was analyzed.

Results: The corrected maximal QT interval (QTcmax) decreased significantly after successful renal transplant compared to prehemodialysis (P=0.002) and posthemodialysis (P=0.003) with a paired t test and a General Liner Model Repeated Measure (P<0.001) between the 3 groups. Also, the mean of QTcmax decreased significantly after renal transplant (P=0.001) compared to what it was before hemodialysis and after hemodialysis. There was a significant correlation (r=-0.37) between reduction of QTcmax and serum Ca level (P=0.01) in postrenal transplant period.

Conclusions: Renal transplant with normal graft function decrease QTcmax compared to pre­hemodialysis and posthemodialysis that may correlate with normalization of electrolytes from the uremic state of the normal kidney function.

Key words: QT interval, Renal transplant, Hemodialysis, Cardiovascular disease, Repolarization

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Incidence of malignancy after living kidney transplantation: a multicenter study from Iran

موضوع: 2012/3

نویسندگان:

استاد راهنما:

خلاصه:

Einollahi B, Rostami Z, Nourbala MH, Lessan-Pezeshki M, Simforoosh N, Nemati E, Pourfarziani V, Beiraghdar F, Nafar M, Pour-Reza-Gholi F, Mazdeh MM, Amini M, Ahmadpour P, Makhdoomi K, Ghafari A, Ardalan MR, Khosroshahi HT, Oliaei F, Shahidi S, Abbaszadeh S, Fatahi MR, Hiedari F, Makhlogh A, Azmandian J, Samimagham HR, Shahbazian H, Nazemian F, Naghibi M, Khosravi M, Monfared A, Mosavi SM, Ahmadi J, Jalalzadeh M. J Cancer. 2012; 3:246-56. doi:10.7150/jca.3042.

شماره: 12

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جزئیات

Journal of Cancer, 2012; 3: 246-256. doi: 10.7150/jca.3042

Incidence of malignancy after living kidney transplantation: a multicenter study from Iran.

Behzad Einollahi1, Zohreh Rostami1, Mohammad Hossein Nourbala1, Mahboob Lessan-Pezeshki2, Naser Sim-foroosh3, Eghlim Nemati1, Vahid Pourfarziani1, Fatemeh Beiraghdar1, Mohsen Nafar3, Fatemeh Pour-Reza-Gholi3, Mitra Mahdavi Mazdeh2, Manochehr Amini2, Pedram Ahmadpour3, Khadijeh Makhdoomi4, Ali Ghafari4, Mohammad Reza Ardalan5, Hamid Taebi Khosroshahi5, Farshid Oliaei6, Shahrzad Shahidi7, Shahin Abbaszadeh1, Mohammad Reza Fatahi1, Fatemeh Hiedari1, Atehieh Makhlogh8, Jalal Azmandian9, Hamid Reza Samimagham10, Heshmatollah Shahbazian11, Fatemeh Nazemian12, Massih Naghibi12, Masoud Khosravi13, Ali Monfared13, Seyed Majid Mosavi14, Javad Ahmadi15, Mojgan Jalalzadeh16

1. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

2. Departement of Nephrology, Tehran University of Medical Sciences, Tehran, Iran.

3. Departement of kidney transplantation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4. Departement of Nephrology, Urmia University of Medical Sciences, Urmia, Iran.

5. Departement of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran.

6. Departement of Nephrology, Babol University of Medical Sciences, Babol, Iran.

7. Departement of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.

8. Departement of Nephrology, Sari University of Medical Sciences, Sari, Iran.

9. Departement of Nephrology, Kerman University of Medical Sciences, Kerman, Iran.

10. Departement of Nephrology, Bandar Abbas University of Medical Sciences, Bandar Abbas, Iran.

11. Departement of Nephrology, Ahvaz University of Medical Sciences, Ahvaz, Iran.

12. Departement of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran.

13. Departement of Nephrology, Rasht University of Medical Sciences, Rasht, Iran.

14. Departement of Nephrology, Ghom University of Medical Sciences, Ghom, Iran.

15. Departement of Nephrology, Artesh University of Medical Sciences, Tehran, Iran.

16. Departement of Nephrology, ZanjanUniversity of Medical Sciences, Zanjan, Iran.

Corresponding author: Zohreh Rostami, MD. Nephrology and Urology

Received: 2011.05.21; Accepted: 2011.08.09; Published: 2012.06.05

ABSTRACT                                                        Full-Text PDF

Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59% of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2%. Kaposis’ sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95% CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation.

Key words: malignancy, kidney transplantation, incidence.

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فایل های مربوطه:

Evaluation of graft survival and related factors among renal transplant recipients in north of Iran from 1999 to 2010: 409

موضوع: 2012/94

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Kohani M, Khosravi M, Orangpour R, Mokhtari GR. Transplantation. 2012 Nov 27 (Supplement: Meeting Abstracts of the 24th International Congress of the Transplantation Society, Berlin, Germany); 94(10S):1088.

شماره: 13

واحد صادرکننده:

جزئیات

Evaluation of Graft Survival and Related Factors among Renal Transplant Recipients in North of Iran from 1999 to 2010

Monfared A.1, Kohani M.2, Khosravi M.1, Orangpour R.3, Mokhtari G.R.4

1Guilan University of Medical Science, Nephrology, Rasht, Iran, Islamic Republic of, 2Guilan University of Medical Science, Internal Medicine, Rasht, Iran, Islamic Republic of, 3Guilan University of Medical Science, Pediatric, Rasht, Iran, Islamic Republic of, 4Guilan University of Medical Science, Urology, Rasht, Iran, Islamic Republic of

ABSTRACT                                                                       PDF

Introduction: Renal transplantation is the modality of choice for renal replacement therapy in the majority of ESRD patients. The survival of transplant kidney was improved significantly with introduce of new immunosuppressive regimens. The determinators of graft survival are relatively known, but conflicting results have been reported. In this study we evaluated graft survival among renal transplant recipients in Razi Hospital of Rasht in North of Iran from 1999 to 2010.

Methods: All kidney transplant recipients in our center (n=273) were studied. The effect of the following parameters on graft survival including sex, donor age, recipient age, cause of renal failure, panel-reactive antibody titer, delayed graft function (DGF) and diabetes mellitus was investigated. Then 1, 5, and 10 years survival analyzed with “Analysis Survival Data” and “Kaplan-Meier curve”. Χ2 test, Independent t-test and Mann-Whitney test were used for analysis of variates.

Results: In this study 1 year survival was 92.6±1.6%, 5years survival was 88±2.1% and 10 years survival was 77.5±3.9%. All grafts were donated from living donor and all of them were non relative. Delayed graft function and diabetes mellitus significantly correlate with short term and long term graft survival (P<0.001). For example one year graft survival among patients with DGF and diabetes mellitus was respectively 50.8±9.89% and 79.6±7.49%. Also in Cox regression model, donor age affects on prediction of graft survival.

Conclusion: In this study 1 year survival (92/6 1/6%), compared with a multicenter study in USA (93/9%) showed good situation in this center. Also results of this study about effect of delayed graft function on graft survival are similar to many studies. Therefore, in order to improve the long-term graft survival, scientific efforts should focus on increase our understanding of delayed graft function.

Citation: Monfared A, Kohani M, Khosravi M, Orangpour R, Mokhtari GR. Evaluation of graft survival and related factors among renal transplant recipients in north of Iran from 1999 to 2010: 409. Transplantation. 2012 Nov 27 (Supplement: Meeting Abstracts of the 24th International Congress of the Transplantation Society, Berlin, Germany); 94(10S):1088.

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The survey of diastolic function changes in end-stage renal disease patients before and 3 and 6 months after kidney transplantation

موضوع: 2012/44

نویسندگان:

استاد راهنما:

خلاصه:

Salari A, Monfared A, Fahim SH, Khosravi M, Lebadi M, Mokhtari G, Pourreza F, Shakiba M. Transplant Proc. 2012 Dec; 44(10):3007-12. doi:10.1016/j.transproceed.2012.03.060.

شماره: 14

واحد صادرکننده:

جزئیات

Transplantation Proceedings, 2012 Dec; 44(10):3007-12. doi:10.1016/j.transproceed.2012.03.060.
The survey of diastolic function changes in end-stage renal disease patients before and 3 and 6 months after kidney transplantation.
A. Salari, A. Monfared, S.H.S.N. Fahim, M. Khosravi, M. Lebadi, G. Mokhtari, F. Pourreza, and M. Shakiba
ABSTRACT                                                        Full-Text PDF
Introduction: Left ventricular diastolic dysfunction, which is prevalent in end-stage renal disease, predicts morbidity and mortality among affected patients. The aim of this study was to evaluate diastolic function changes in end-stage renal disease patients before as well as 3 and 6 months after kidney transplantation.
Methods and materials: This longitudinal study from November 2008 to November 2009, enrolled 27 consecutive kidney transplant patients. Systolic and diastolic blood pressures and echocardiograghic parameters such as ejection fraction, left ventricular mass, and diastolic functions were measured before, as well as 3 and 6 months after transplantation. Data were analyzed by repeated-measure analysis of variance and Friedman tests using SPSS version 18.
Results: The mean patients age was 39.47±12.27 years with 55.6% males. The mean systolic and diastolic blood pressure and left ventricular mass decreased significantly in the first 3 (125.44±11.35, 78.51±6.32, 141.94±3.32) and 6 months (121.48±10.63, 72.96±4.21, 138.25±3.12) after renal transplantation compared to the values before the procedure (136.77±14.09, 81.92±9.01, 158.30±3.58 respectively; P<0.05). The left ventricular ejection fraction increased significantly at 3 (63.00±6.49) and 6 months (66.11±5.87) compared with preoperative (62.48±5.74; P<0.05). Step mean diastolic function also decreased significantly at 3 (1.94) and 6 months (1.81) compared with before transplantation (2.24; P<0.05).
Conclusion: According to our findings, transplantation can correct ejection fraction and systolic and diastolic blood pressure and lead to regression of left ventricular hypertrophy. Diastolic function was improved after transplantation.

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Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran

موضوع: 2014/98

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Azimi SZ, Kazemnezhad E, Khosravi M, Lebadi M, Mirzajani E, Ashtiani MN. Transplantation. 2014 Jul 15; 98(1):66-71. doi:10.1097/01.TP.0000443222.82207.3d.

شماره: 15

واحد صادرکننده:

جزئیات

Transplantation. 2014 Jul 15; 98(1):66-71. doi:10.1097/01.TP.0000443222.82207.3d.
Hyperhomocysteinemia and assessment of its associated factors in renal transplant recipients: a single-center study in northern Iran.
Ali Monfared,1 Seyyede Zeinab Azimi,1,3 Ehsan Kazemnezhad,1 Masoud Khosravi,1 Mohammadkazem Lebadi,1 Ebrahim Mirzajani,2 and Mohammad Najafi Ashtiani2
1 Urology Research Center, School of Medical, Guilan University of Medical Sciences, Rasht, Iran.
2 School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
3 Address correspondence to: Seyyede Zeinab Azimi, M.D., Urology Research Center, School of Medical, Guilan University of Medical Sciences, Department of Nephrology, Razi Hospital, Rasht, Iran. E-mail: sz.azimi@yahoo.com
Received 11 February 2013. Revision requested 11 March 2013.
Accepted 9 December 2013.
ABSTRACT                                                        Full-Text PDF
Introduction: Hyperhomocysteinemia (hyperHcy) is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients (RTRs). The aim of this study was to determine the associated factors of hyperHcy in RTRs in northern Iran.
Methods: In 148 stable RTRs, total serum homocysteine (tHcy) level, folate, serum albumin and creatinine, creatinine clearance, lipid status, body mass index (BMI), and blood cyclosporine levels (C0 and C2) were determined. The mean doses of cyclosporine A (mg/kg/day) were recorded.
Results: In this analytic cross-sectional study the prevalence of hyperHcy was 70.3%. Hyperhomocysteinemia was defined as total serum homocysteine of 12 Kmol/L or greater. The comparison of the group of 44 patients with tHcy level less than 12 and the group of 104 patients with tHcy level of 12 Kmol/L or greater revealed that those subjects with hyperHcy were mostly younger, male, with lower BMI, history of glomerulonephritis, higher serum level of uric acid, and blood cyclosporine trough level (C0) and used higher doses of cyclosporine A. Significant correlation was found between tHcy level and recipients age, serum creatinine, BUN, folate concentrations, and creatinine clearance. However, multivariate analysis indicated that serum folate (P=0.01), vitamin B12 (P=0.05), creatinine (P=0.03), and BUN (P=0.05), and blood cyclosporine trough level (C0, P=0.005) were independently associated with tHcy levels.
Conclusion: HyperHcy persists after successful kidney transplantation in the majority of RTRs. Serum creatinine, BUN, folate and vitamin B12, and blood cyclosporine trough level (C0) are independently associated with tHcy levels.
Keywords: Atherosclerosis, Homocysteine, Hyperhomocysteinemia, Kidney transplantation, Risk factors.

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فایل های مربوطه:

Allograft survival rate and analysis of predictor factors in kidney transplant recipients from living donors

موضوع: 2014/21

نویسندگان:

استاد راهنما:

خلاصه:

Rostami S, Monfared A, Pourreza F, Kazemnezhad E, Khosravi M, Lebadi M, Kohani M, Mokhtari G, Hemmati H, Orangpour R, Rahimifar S. International Journal of Urology 2014 Dec 1 (Supplement: Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5th-9th, 2014, Kish Island, Iran. published online: 26 DEC 2014. doi:10.1111/iju.12708_2); 21(S2):A263-A263.

شماره: 16

واحد صادرکننده:

جزئیات

International Journal of Urology (2014) 21. Suppl 2. Page A263

Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5th-9th, 2014, Kish Island, Iran

OP.8.8Dec.8

ALLOGRAFT SURVIVAL RATE AND ANALYSIS OF PREDICTOR FACTORS IN KIDNEY TRANSPLANT RECIPIENTS FROM LIVING DONORS

Sadegh Rostami, Ali Monfared, Farshid Pourreza, Ehsan Kazemnezhad, Masoud Khosravi, Mohammadkazem Lebadi, Maryam Kohani, Gholamreza Mokhtari, Hossein Hemmati, Reza Orangpour, Shahrzad Rahimifar

ABSTRACT PDF

Aim: to determine graft survival rate and possible related factors in 273 living donor renal transplant recipients in a single center from 1999 to 2010.

Methods: Organ survival and demographic characteristics and variables that may affect graft survival rate were evaluated in all renal allograft recipients in Razi Hospital of Rasht in North of Iran. Chi-square, Independent T-Test and Mann-Whitney were used for analysis of variates. Survival rate was estimated by “Kaplan-Meier method”, and Tarone-Ware test were applied for comparing survival rates. Multivariate analysis was also done by COX regression model.

Results: In this study, 1-, 5- and 10 year graft survival rates were 92.6±1.6, 88±2.1 and 77.5±3.9%, respectively. Delayed graft function was significantly correlated with graft survival rate (P<0.001). Furthermore, It was the only statistically significant predictor of graft loss (p<.00). Worse graft survival rate was observed in patients with diabetes (p<0.018).

Conclusions: Although the survival rate in our center is comparable with the reports of other great centers in the world, focusing on Modification of some variables may improve transplant outcomes.

Citation: Rostami S, Monfared A, Pourreza F, Kazemnezhad E, Khosravi M, Lebadi M, Kohani M, Mokhtari G, Hemmati H, Orangpour R, Rahimifar S. Allograft survival rate and analysis of predictor factors in kidney transplant recipients from living donors. International Journal of Urology 2014 Dec 1 (Supplement: Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5th-9th, 2014, Kish Island, Iran. published online: 26 DEC 2014. doi:10.1111/iju.12708_2); 21(S2):A263-A263.

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فایل های مربوطه:

Studying the association between atorvastatin and total plasma homocysteine levels in renal transplant recipients in north of Iran

موضوع: 2014/21

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Monfared A, Azimi SZ, Kazemnezhad E. International Journal of Urology 2014 Dec 1 (Supplement: Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5th-9th, 2014, Kish Island, Iran. published online: 26 DEC 2014. doi:10.1111/iju.12708_2); 21(S2):A268-A268.

شماره: 17

واحد صادرکننده:

جزئیات

International Journal of Urology (2014) 21. Suppl 2. Page A268
Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5th-9th, 2014, Kish Island, Iran
OP.8.8Dec.17
STUDYING THE ASSOCIATION BETWEEN ATORVASTATIN AND TOTAL PLASMA HOMOCYSTEINE LEVELS IN RENAL TRANSPLANT RECIPIENTS IN NORTH OF IRAN
Ali Monfared, Seyyede Zeinab Azimi , Ehsan Kazemnezhad
ABSTRACT                                                                        PDF
Aim: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTR). The objective of our study was to evaluate the association between plasma total homocysteine (tHcy) levels and atorvastatin in RTRs.
Method: We performed a retrospective cross-sectional study in 148 cyclosporine treated stable RTRs. We compared tHcy level in RTRs with and without atorvastatin.
Results: Mean tHcy levels were lower in patients with atorvastatin (20-40 mg/day) compared to nonusers (15.06±5.65 μmol/L, 17.91±10.85; P=0.04). The comparison of the group of 86 patients with atorvastatin and 62 non-users revealed that those subjects with atorvastatin were older, with higher HDL levels, eCrCl and BMI. They were more likely to have diabetes, higher systolic blood pressure and CsA trough level (C0). The association between lower tHcy levels and atorvastatin was confirmed in the multivariate regression model (P=0.004). However tHcy levels were negatively associated with serum folate (P=0.0001) and vitamin B12 levels (P=0.001) and positively with serum BUN (P=0.0001) and diastolic blood pressure (P=0.024) as well.
Conclusion: These data support the association between lower tHcy levels and atorvastatin usage in RTRs. Further clinical trials are recommended to clarify homocysteine lowering effect of atorvastatin
Citation: Monfared A, Monfared A, Azimi SZ, Kazemnezhad E. STUDYING THE ASSOCIATION BETWEEN ATORVASTATIN AND TOTAL PLASMA HOMOCYSTEINE LEVELS IN RENAL TRANSPLANT RECIPIENTS IN NORTH OF IRAN. In INTERNATIONAL JOURNAL OF UROLOGY 2014 Dec 1 (Vol. 21, pp. A268-A268). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.

ملاحظات:

فایل های مربوطه:

Studying the association between atorvastatin and total plasma homocysteine levels in renal transplant recipients in north of Iran

موضوع: 2015/28

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Azimi SZ, Kazemnezhad E. Transplant International. 2015 Nov 1 (Special Issue: Abstracts of the 17th Congress of the European Society for Organ Transplantation 13-16 September 2015, Brussels, Belgium. Published online: 17 NOV 2015. doi:10.1111/tri.12702); 28(S4):537-537.

شماره: 18

واحد صادرکننده:

جزئیات

Abstracts of the 17th Congress of the European Society for Organ Transplantation

P382

STUDYING THE ASSOCIATION BETWEEN ATORVASTATIN AND TOTAL PLASMA HOMOCYSTEINE LEVELS IN RENAL TRANSPLANT RECIPIENTS IN NORTH OF IRAN

Ali Monfared, Seyyede Zeinab Azimi, Ehsan Kazemnezhad

Urology Research Center, Guilan University of Medical Sciences

ABSTRACT PDF

Introduction: Statins improve prognosis in patients with coronary heart diseases by decreasing the incidence of vascular events. Excess prevalence of hyperhomocysteinemia, an independent risk factor of cardiovascular diseases, has been observed in stable renal transplant recipients (RTR). The objective of our study was to evaluate the association between plasma total homocysteine (tHcy) levels and atorvastatin in RTRs.

Method: We performed a retrospective cross-sectional study in 148 cyclosporine treated stable RTRs. We compared tHcy level in RTRs with and without atorvastatin.

Results: Mean tHcy levels were lower in patients with atorvastatin (20–40 mg/day) compared to nonusers (15.06±5.65 μmol/L, 17.91±10.85; P=0.04). The comparison of the group of 86 patients with atorvastatin and 62 non-users revealed that those subjects with atorvastatin were older, with higher HDL levels, eCrCl and BMI. They were more likely to have diabetes, higher systolic blood pressure and CsA trough level (C0). The association between lower tHcy levels and atorvastatin was confirmed in the multivariate regression model (P=0.004). However tHcy levels were negatively associated with serum folate (P=0.0001) and vitamin B12 levels (P=0.001) and positively with serum BUN (P=0.0001) and diastolic blood pressure (P=0.024) as well.

Conclusion: These data support the association between lower tHcy levels and atorvastatin usage in RTRs. Further clinical trials are recommended to clarify homocysteine lowering effect of atorvastatin.

Model

β Coefficients ± SE

t

p

95% Confidence interval for β

Constant

12.22 ± 2.06

5.93

0.000

8.15–16.29

Atorvastatin

2.85 ± 1.37

2.08

0.040

0.14–5.59

Citation: Monfared A, Azimi SZ, Kazemnezhad E. STUDYING THE ASSOCIATION BETWEEN ATORVASTATIN AND TOTAL PLASMA HOMOCYSTEINE LEVELS IN RENAL TRANSPLANT RECIPIENTS IN NORTH OF IRAN. In TRANSPLANT INTERNATIONAL 2015 Nov 1 (Vol. 28, pp. 537-537). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY-BLACKWELL.

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The authors' reply

موضوع: 2014/98

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Azimi SZ, Kazemnezhad E, Khosravi M, Lebadi M, Mirzajani E, Ashtiani MN. Transplantation. 2014 Dec 15; 98(11):e89-90. doi:10.1097/TP.0000000000000494.

شماره: 19

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جزئیات

Transplantation. 2014 Dec 15; 98(11):e89-90. doi:10.1097/TP.0000000000000494.
The authors' reply.
Ali Monfared1, Seyyede Zeinab Azimi1, Ehsan Kazemnezhad1, Masoud Khosravi1, Mohammadkazem Lebadi1, Ebrahim Mirzajani2, Mohammad Najafi Ashtiani2
1Urology Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Address correspondence to: Seyyede Zeinab Azimi M.D., Urology Research Center, School of Medical, Guilan University of Medical Sciences, Department of Nephrology, Razi Hospital, Rasht, Iran. E-mail: sz.azimi@yahoo.com
Received 2 September 2014.
Accepted 8 September 2014.

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فایل های مربوطه:

Comparison of Tpe changing on ECG, in pre and post dialysis and post transplantation

موضوع: 2016/8

نویسندگان:

استاد راهنما:

خلاصه:

Monfared A, Rad MA, Feizkhah M, Kazemnezhad E, Esmaeili S, Herfeh NR, Hedayatsafa R. Nephro-Urology Monthly. 2016 March 26; 8(3):e35864. doi:10.5812/numonthly.35864.

شماره: 20

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جزئیات

Nephro Urol Mon. 2016 March 26; 8(3):e35864. doi: 10.5812/numonthly.35864.
Research Article
Comparison of Tpe Changing on ECG, in Pre and Post Dialysis and Post Transplantation
Ali Monfared,1,* Mohammad Assadian Rad,2 Mohammadreza Feizkhah,1 Ehsan Kazemnezhad,1 Samaneh Esmaeili,1 Nadia Rastjou Herfeh,1 and Razieh Hedayatsafa1
1Urology Research Center, Guilan University of Medical Sciences, Rasht, IR Iran
2Cardiology Research Center, Guilan University of Medical Sciences, Rasht, IR Iran
*Corresponding author: Ali Monfared, Urology Research Center, Guilan University of Medical Sciences, Rasht, IR Iran. Tel: +98-1315525259, E-mail: drmonfared2009@gmail.com
Received 2015 December 30; Revised 2016 February 17; Accepted 2016 March 02.
ABSTRACT                                                        Full-Text PDF
Background: High incidence of premature ventricular contractions (PVCS) and arrhythmia during and soon after dialysis have been demonstrated by Holter monitoring.
Objectives: In this study, the effects of dialysis and renal transplantation on Tpe, Tpec (corrected Tpe), QTc (corrected QT), QTd (QT dispersion), and Tpe/QT parameters as known factors in arrhythmogenicity, and also the correlation between electrolyte and arterial blood gas changing within these parameters will be assessed.
Patients and Methods: In a retrospective study, 42 renal transplant recipients were selected. Under the supervision of an electrophysiologist, information related to Tpe, Tpec, Tpe/QT, QTd, and QTc parameters before dialysis (pre-HD), after dialysis (post-HD), and two weeks after transplantation (RTX) were analyzed. Electrolyte and arterial blood gas information were also recorded. Bonferroni adjustment, repeated measures ANOVA, generalized linear models, and generalized estimating equations were used for analysis.
Results: Two weeks after transplantation, the mean Tpe decreased to 0.052±0.002, which was significant compared to pre-HD (P<0.001) and Post-HD (P=0.019). The mean Tpec was 0.059±0.002, which, just in comparison to pre-HD, was significant (P=0.005). In addition, the mean Tpe/QT decreased to 0.143±0.005, which was significant compared to pre-HD (P=0.018). The mean QTd was 0.066±0.004, which wasn’t significant compared to before or after dialysis. The mean QTc decreased to 0.386±0.004, which was significant compared to post-HD (P=0.0003).
Conclusions: Taking the role of Tpe and Tpe/QT in arrhythmia into account and amending it by a successful transplantation can be considered as a factor that decreases arrhythmia after renal transplantation compared to ESRD patients. (Reviewer comments-1).
Keywords: Tpe, Failure, ESRD, Hemodialysis, Transplant, Electrolyte

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تستستتتتت 96

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شماره: 5565

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غفثقق3قث2

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تست 97

موضوع: تست 97

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شماره: 100

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ل4فلضض34ق23

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دانلود

ergef

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شماره: 986

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yhjnwrgtqwer

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آخرین بروز رسانی : 1278/10/11